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Study Reports Gadolinium Clearance Times for 135 Contrast MRI Cases including Agent Administered for 63 Unconfounded Cases
On December 5, 2018, Hubbs Grimm and Sharon Williams, coauthors of GadoliniumToxicity.com, released their fifth research paper on gadolinium retention from Gadolinium-based Contrast Agents (GBCAs) administered for contrast-enhanced MRIs. The paper is titled Gadolinium Clearance Times for 135 Contrast MRI Cases and includes the contrast agents for the unconfounded cases.
Drawing on the contrast MRI history and 24-hour gadolinium urine testing results that have been received from members of the MRI-Gadolinium-Toxicity Support Group, the study reports retrospectively on 135 cases with 218 urine test results, including 63 unconfounded cases with 81 test results. The participants all had normal kidney function and report having symptoms of gadolinium toxicity. The results reported are dramatic and involve all linear and macrocyclic GBCAs currently in use in the United States.
About the Gadolinium Clearance Time Report
In addition to reporting on additional cases received since our previous paper in 2017, we now report the contrast agents received with each unconfounded case. Analysis of the these cases produced trend lines over time that indicate typical gadolinium found in 24-hour urine testing for each of the agents including Dotarem, Gadavist, Magnevist, MultiHance, Omniscan, OptiMARK, and ProHance. The graphs and tables provide helpful information for both patients and medical practitioners trying to understand their test results. The analysis of clearance times for each agent is presented on a separate page.
The results show that all agents, both linear and macrocyclic, do not clear from the body in a few days as most patients are told. None of the test results in the first 2.5 months following a contrast-enhanced MRI was within the reference range used by Mayo Clinic Laboratories. It should be noted that the contrast agent and test result information presented is from people who believe they are suffering symptoms of gadolinium toxicity since their contrast-enhanced MRI. It is not known whether the clearance times presented would also apply to individuals who are not symptomatic.
The complete set of test results, without any data that would identify patients, is available to other researchers upon request.
With the evidence provided that clearance times are much longer for all of the agents than expected by medical practitioners, the authors present five recommendations for needed actions by medical professionals, other researchers, government agencies, and contrast agent manufacturers.
We want to thank members of the MRI-Gadolinium-Toxicity Support Group for their willingness to share their test results and other information with us. Our papers would not be possible without their continued support.
We urge patients, clinicians, and researchers to read the entire report and share as appropriate with your families, caregivers, and colleagues.
Hubbs Grimm and Sharon Williams
My first urine test for Gadolinium was not done until a full two years after my last dose of contrast. Part of the delay was because I did not know about the test until almost 18 months had gone by.
I wanted my first test to be performed by Mayo Clinic Labs; however, I had difficulty making that happen. The lab affiliated with the medical clinic where most of my doctors are located told me that they could not do any testing for heavy metals or send specimens out to another lab for the testing. But I finally found a way around that problem.
The lab at our local hospital regularly sends specimens to Mayo Clinic in Rochester, Minnesota. (more…)
(A PDF of this Viewpoint is available for download.)
This is a re-written version of some emails that I have sent on the subject, so please read it with that in mind. They were addressed to several people in the MRI-Gadolinium Toxicity Support Group.
A word before you read this. I usually do not post this kind of thinking on the support group because many people hold out chelation as their only hope. I do not want to squelch their hope and I do not just want to be negative on it. As you will see below, I have tried it and decided that it is not for me. So I just tell my story. Everyone has to make their own decisions.
Let me provide some background. My last contrast MRI (of 8 in total) was in October 2009 when I had three contrast MRIs within a two-week period. (more…)
I did Genova Diagnostics through my local Health and Wellness Dr. But there is a web site that I would not be afraid to use because of the way the process works.
The Dr. just gives me a box with everything necessary including instructions for how to do it and how to FedEx it in with a prepaid FedEx label.