In January of 2015, another study by Kanda et al was published online ahead of print in Radiology.  The study, High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration, evaluated MR images of 127 patients who had undergone contrast-enhanced brain MRIs at their institution in Japan.  The images of nine patients (7.1%) showed hyperintensity in the Dentate Nucleus (DN) on unenhanced T1-weighted MR images – none of the patients had severe renal disease.  Of those nine patients, 7 received only linear GBCA and 2 received both a linear and macrocyclic GBCA.  The contrast agents were Magnevist and ProHance.  After thorough analysis, the authors concluded that hyperintensity in the DN on unenhanced-T1 weighted MR images was associated with previous administration of the linear GBCA, but not with the macrocyclic GBCA. (more…)