Gadolinium Toxicity

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Breaking News

breakingnews

March 10, 2017 - European group recommends to stop using 4 linear GBCAs Read all about it.

February 27, 2017 - New Study Reports Gadolinium Retention in 70 Cases with Normal Kidney Function. Read all about it.

Our Library contains copies of information we have created as well as links to other important documents and resources.  Due to Copyright Restrictions, we cannot provide PDFs of published articles on our website.  In many cases, articles referenced in the links provided below will be available for free download directly from the publisher.

Researching Gadolinium Toxicity is not an enjoyable task, but we hope you find helpful information in our Library and throughout the rest of our website.

Our Research

Overview of Gadolinium Toxicity – March 2012
Our first paper is a literature review of over 100 medical research papers containing information related to the toxicity of Gadolinium retained in the human body from Gadolinium-Based Contrast Agents.  Footnotes are provided for each valuable source.

A Group Self-Study of Retained Gadolinium from Contrast MRIs – October 2013
Our second paper published, for the first time, an original research project reporting levels of retained Gadolinium in urine from Contrast MRIs extending out as far as 5 years.  Graphs are provided in this effort that attracted the attention of the MRI community.

Survey of the Chronic Effects of Retained Gadolinium – April 2014
Our third paper presents the Symptoms attributed to Gadolinium Toxicity by 17 people with elevated levels of Gadolinium in their urine.  The commonality of the symptoms provides strong evidence of a link to contrast MRIs.

Other Files and Links

The links provided here are a small selection of important Gadolinium-related research material.  We encourage you to read the comprehensive information provided in the Background section to understand how these resources fit into the overall picture.  Please note that we have no connection to any of the resources listed here and that our listing of them does not indicate any form of endorsement of the content provided.

The International Center for Nephrogenic Systemic Fibrosis Research (ICNSFR)
A website regarding NSF. Cowper SE. Nephrogenic Systemic Fibrosis [ICNSFR Website]. 2001-2013. Available at http://www.icnsfr.org. Accessed 9/21/2014.

Nephrogenic Systemic Fibrosis: History, Diagnosis and the Registry by Dr. Shawn Cowper (2009)
The slide presentation contains photos and other information that is included in the 2011 “Nephrogenic systemic fibrosis: Clinicopathological definition and workup recommendations” by Girardi et al which provides guidance to physicians for the evaluation and diagnosis of NSF.

Roentgen Ray Reader: New Proposed Criteria for Diagnosis of Nephrogenic Systemic Fibrosis (2011)
This blogspot is another source for the major and minor criteria for diagnosing NSF as well as information on the histologic findings.

Global Fibrosis Foundation
A not-for-profit organization whose mission is to help educate patients, families and the medical community about Nephrogenic Systemic Fibrosis and other organ specific fibrosing processes; to support research into prevention and treatment; and to advocate on behalf of patients.

American Board of Magnetic Resonance Safety (ABMRS)
The formation of the ABMRS was announced January 2015.  The not-for-profit corporation’s purpose is to improve the safety of medical and research magnetic resonance (MR) environments.  That includes the safety of MR facilities and the certification and qualification of the professionals who oversee the physical and operational safety of the MR equipment, environment, and processes.

ACR Manual on Contrast Media, Version 9 – 2013 – American College of Radiology.
The manual contains information on Gadolinium-based Contrast Agents and NSF.

Choosing Wisely®
Is an initiative of the ABIM Foundation to help providers and patients engage in conversations to reduce overuse of tests and procedures, and support patients in their efforts to make smart and effective care choices.

European Medicines Agency Assessment Report of Gadolinium-containing Contrast Agents, July 2010.
This contains the latest report from the EMA on Gadolinium-based Contrast Agents.

ESUR (European Society of Urogenital Radiology) – Nephrogenic Systemic Fibrosis and Gadolinium-based Contrast Media: Updated ESUR Contrast Medium Safety Committee Guidelines (2012)

MHRA (UK Public Assessment Reports) Gadolinium-containing MRI Contrast Agents: Nephrogenic Systemic Fibrosis (2010)

MRI Patient Safety Blog
The blog provides information for MRI patients as well as technologists/radiographers, radiologists, and those who visit or occasionally need to work near MRI scanners and equipment.

MRI Safety.com
The website of the Institute for Magnetic Resonance Safety, Education, and Research.

#MRIsafety
A Twitter feed of the hashtag #MRIsafety.  You will find up-to-date tweets from medical practitioners and others concerned with MRI safety.

Six years after by Henrik Thomsen and Charles Bennett (2012) 
Six years after the connection was made between NSF and GBCAs, this short article poses some questions about what have we learned.  Of interest is what was already known about Gadolinium and linear GBCAs by 1995, but not acted upon.

Thorotrast Toxicity: the Safety of Gadolinium Compounds by J.F.M. Wetzels (2007)
Thorotrast was a radiocontrast agent used from 1930 to 1960.  It wasn’t until the late 1940s that the first “Thorotrast-related malignancies” were described and the problem came to light.  Could Gadolinium-based Contrast Agents be the next Thorotrast?

Inspirational or Coping Files

Enjoy the Ride – an inspirational slide show
We found this and have personally been inspired to forge ahead in spite of the effects of Gadolinium Toxicity.  From it, Duke G has adopted the motto of “Get Up, Dress Up, and Show Up”


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