Gadolinium Toxicity

Home » Posts tagged 'GLOS'

Tag Archives: GLOS

Viewpoint Categories

NIH study finds unexpected leakage of gadolinium into eyes of stroke patients

On February 7, 2018, researchers from the National Institutes of Health (NIH) reported on the unexpected finding of gadolinium leakage into ocular structures (GLOS) in acute stroke patients after administration of a gadolinium-based contrast agent (GBCA).  “Blood-ocular barrier disruption in acute stroke patients” by Hitomi et al. is published in the journal Neurology.  Blood-ocular barriers (BOBS) protect the compartments of the eye.

NIH researchers performed baseline MRI scans with a gadolinium-based contrast agent on 167 stroke patients upon admission to the hospital and compared them to scans performed 2 and/or 24 hours later with fluid-attenuated inversion recovery (FLAIR) imaging.  The study found that gadolinium leakage was evident on post-contrast FLAIR images in 127/167 (76%) patients.  At 2 hours after administration of the GBCA, GLOS was more common in the aqueous chamber alone.  At 24 hours, GLOS was present in 121/162 (75%) patients, always involving the vitreous chamber, but also affecting the aqueous chamber in 6% of cases.

The authors concluded that GLOS is common in patients with acute stroke, and delayed GLOS was a marker for chronic vascular disease. They noted that the mechanism for acute GLOS remains uncertain but may be a remote effect of acute cerebral injury on the blood-ocular barrier.

It remains unclear whether gadolinium can enter the eye in healthy people.

Gadolinium has been detected in eyes before (more…)

%d bloggers like this: