Gadolinium Toxicity

Home » Posts tagged 'Cumulative Dosage' (Page 2)

Tag Archives: Cumulative Dosage

Viewpoint Categories

Mayo study reports Gadolinium remains in the brain after contrast-enhanced MRI

An important new study was published online March 5, 2015 in Radiology.  Dr. Robert McDonald and his colleagues at Mayo Clinic in Rochester, Minnesota, found high levels of gadolinium in four regions of the brain of 13 deceased patients who had 4 or more contrast-enhanced MRIs with Omniscan.  None of the patients had severe renal disease.  Except for one patient with an eGFR of 54, the other 12 had an eGFR between 74 and 122.  The authors concluded that “intravenous GBCA exposure is associated with neuronal tissue deposition in the setting of relatively normal renal function”.

The study, Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging, sought to confirm the findings of Errante et al (2014) and Kanda et al (2103) which reported progressive increases in T1-weighted signal intensity in parts of the brain after repeated administration of a Gadolinium-based Contrast Agent (GBCA). (more…)

Gadolinium-Associated Plaques (GAP) in a patient without renal disease.

On November 12, 2014, an article was published online about a new condition called Gadolinium-Associated Plaques or GAP.  The JAMA Dermatology article by Gathings, Reddy, Santa Cruz, and Brodell is titled, “Case Report/Case Series, Gadolinium-Associated Plaques – A New, Distinctive Clinical Entity”.  The full-article is not freely available online at this time; however, the abstract can be found at

While this case series reports on only 2 patients, its findings are especially significant for patients with normal renal (kidney) function.  Both patients had erythematous plaques which were determined to be sclerotic bodies in various stages of calcification.  Previously these sclerotic bodies were thought to be associated with NSF (Nephrogenic Systemic Fibrosis) in patients with chronic renal disease after exposure to a Gadolinium-based Contrast Agent (GBCA).  The significance of this case series is that neither patient had NSF; while one patient did have renal disease, the other patient did not.  (more…)

Study reports brain abnormalities on MRI in patients with normal kidney function

In the October 2014 issue of Investigative Radiology, Errante et al report study findings that confirm the association between the increase in the unenhanced T1-weighted signal intensity of the dentate nucleus and the number of gadolinium-enhanced MRI scans.  (The dentate nucleus is located within the deep white matter of the brain.)

The study included 38 patients with Multiple Sclerosis (MS) and 37 patients with brain metastases (BMs) who had undergone at least 2 consecutive enhanced MRIs.  After calculating the dentate nuclei-to-pons (DNP) signal intensity ratio, these values were compared between patients with less than 6 and those with 6 or more contrast-enhanced MRI.  A progressive increase in the T1 signal intensity of the DNP ratio was observed in both the MS group and the BM group.  All patients had normal kidney function. (more…)

%d bloggers like this: