Gadolinium Toxicity

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Difference between Linear and Macrocyclic GBCAs

GBCAs can be divided into two categories based on their molecular structure.  Linear and Macrocyclic GBCAs have different properties that may contribute to their propensity to dechelate at some time after administration. This very short video explains the difference between linear and macrocyclic GBCAs and it hits on transmetallation too. (more…)

A Perspective on Gadolinium Toxicity and NSF

As you read more of the published articles about NSF, GBCAs and gadolinium, you will find a lot of confusing and at times conflicting information.  One thing I realized while doing my research is that it is important to consider when the article was published.  It wasn’t until 2006 that the connection was made between NSF and GBCAs, and as time has gone on some of what was said in the earlier articles has been further evaluated which resulted in new facts emerging.

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